The architecture, the landscape, the urban planning, the information technology and the other disciplines merge and move towards extreme evolution.In search of extreme and unusual shapes and heights to overcome a fictitious challenge between power and ability, it is opposed to the need to simplify the representation and make it elementary.The desig
Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism
Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP).CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene, which enco
Assessing the Effect of Variable Ambient Temperature on the Self-ignition of a Reaction-diffusion System Employing a Reduced Order Modelling Methodology
The system under study in this work is a self-igniting pile of solid material.To predict and understand the effect of steep changes of the state variables on such systems, a reaction-diffusion model is employed.These systems can exhibit complex oscillatory behaviour, and changes in ambient conditions over time may strongly impact the inherent oscil
Modeling Structural Equations for Predicting Death Anxiety Associated with COVID-19 Based on Mediating Roles of Emotion Regulation and Meaning in Life
Background and purpose: Life and death became significant issues with the outbreak of the COVID-19 and its aftermath.Previous studies have shown that having meaning in life and the ability to regulate emotion can play effective roles in coping with death anxiety.The present gymnastics wall decals study investigated the relationship between COVID-19